Research and Resources


Our research spans a broad range of topics relevant to the biopharma industry, and has led to several peer-reviewed articles. For more information about our research activities or reprints of paywalled papers, contact us at And, don't forget to scroll to the bottom of the page for some of our "evergreen" resources!


Preventing the next Marathon Pharmaceuticals

In 2017, Marathon Pharmaceuticals obtained U.S. approval for the steroid deflazacort in Duchenne's muscular dystrophy. But the company came under fire for setting a high price for a drug that was long available for a pittance in Europe, despite having spent next to nothing on further research. Can we - and should we - prevent this type of behavior in the future? We analyzed the regulatory and pricing context, and also determined the likelihood of similar scenarios in the future. (Image:

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Under current reimbursement rules, doctors are economically incentivized to administer high-priced infused and injected drugs - but do they really prioritize profits over patients? We used public Medicare data to try to estimate how much money is really at stake, and whether it's likely to change prescribing behavior.

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the myth of "leaner and meaner" pharma

Drug makers commonly tout layoffs and reorganizations as tools to boost productivity. But have they really improved the "return on talent"? We examined total headcount and profit per employee to see if these efforts are paying off.


Value-based healthcare - the customer perspective

Warren Buffett famously said that, "Price is what you pay, value is what you get." But does "clinical value" to patients really matter to the folks who actually pay for medical devices and drugs? We asked hospital CFOs and other financial stakeholders how they evaluate new products in a capitated payment setting, the inpatient operating room. (Spoiler alert: long-term clinical value is nice, but it doesn't balance the books.)


historical trends in pharma R&D spending

Prior analyses of pharma R&D and SG&A spending have focused on each category as a percent of revenues. In this work, we instead look at historical trends over time to discover how drug companies choose to allocate resources, particularly when revenues are pressured.



Pharma regulatory strategy would be radically transformed if the FDA were compelled to automatically consider drugs already approved in other countries for market approval. In this cohort analysis, we measure how U.S. patients could be affected by this proposed policy.

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Drug launch curves in the modern era

The historical view of prototypical drug launches is based on 30-year-old work focused on cardiovascular medicines. Here, we update those data and provide a revised view of ramp rates of "pioneer" and "follower" drugs.

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Clinical development planning and financial analysis are traditionally conducted in separate silos. In this piece, we illustrate the benefits that drug companies can reap by integrating these activities.



Here are some "evergreen" resources we've developed for biomedical innovators - for more information, please contact us at


Pitch deck tips for biotech and medtech start-ups

A Google search for "biotech pitch decks" returns lots of hits - but many of them are irrelevant to drug and device newcos. Have no fear - we've got a list of the best resources for you.


Academic-industry R&D collaborations

Many pharma companies are fostering external collaborations via "open innovation" initiatives. We've compiled a directory of industry programs that provide compounds, resources, and funding to academic investigators.